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Abstract #3003

Correlation time mapping of degenerated human and bovine articular cartilage reveals tissue structure and degenerative changes

Hassaan Elsayed1,2,3,4, Matti Hanni2,3,4, Jari Rautiainen2,3,5, Mikko Johannes Nissi5,6, and Miika Nieminen2,3,4

1Computer Science and Engineering, University of Oulu, Oulu, Finland, 2Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 3Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 4Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 5Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 6Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland

Correlation time ($$$\tau_c$$$) maps were obtained by fitting $$$\tau_c$$$ from $$$T_{1\rho}$$$ dispersion measurements of human articular cartilage specimens and enzymatically digested bovine samples to develop a new MRI contrast which characterizes tissue properties at molecular level. $$$\tau_c$$$ revealed the laminar appearance in control and PG depleted bovine specimens, which was not observable in the collagen-digested specimens. The laminar appearance was also visible in the early OA human specimens, in contrast to the advanced OA group. The results demonstrated that $$$\tau_c$$$ mapping is a potential method for providing information about the articular cartilage structure and associated changes with degeneration.

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