Abstract #3002

T2* Based MRI Temperature Contrast

Janusz Henryk Hankiewicz¹, Jason Nobles¹, Zbigniew Celinski¹, Karl Stupic², and Robert Camley¹

¹UCCS Center for Biofrontiers Institute, University Colorado Colorado Springs, Colorado Springs, CO, United States, ²National Institute of Standards and Technology, Boulder, CO, United States

The aim of this study was to develop a novel temperature-sensitive MRI contrast agent based on temperature changes of the magnetic moment of magnetic particles. Gadolinium was used to test the hypothesis that magnetic particles will create a temperature-dependent local dipole magnetic field. This effect was locally visible as a temperature dependent darkening on gradient-echo MRI images. Shades of gray within the images can then be calibrated to map the local temperatures in specific areas of tissue during medical procedures. The estimated accuracy of temperature determination deep in the phantom using MR image intensity is ±1.8^oC, at 37^oC.

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