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Abstract #3009

Impact of sequence parameters on the sensitivity of DDE and DODE sequences to microscopic anisotropy

Andrada Ianuș1, Ivana Drobnjak1, Noam Shemesh2, and Daniel C. Alexander1

1CMIC, University College London, London, United Kingdom, 2Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal

In the long mixing time regime, double-diffusion-encoding (DDE) sequences provide contrast capable of reflecting microscopic anisotropy, which may have added value for highly heterogeneous tissues such as the gray matter. Recently, double-oscillating-diffusion-encoding (DODE) sequences, which combine oscillating waveforms and varying gradient orientation, have been proposed to improve sensitivity to microscopic anisotropy. This work investigates the effect of varying different sequence parameters and shows that DODE sequences provide higher sensitivity to pore size for elongated pores, while DDE sequences are more sensitive to pore eccentricity.

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