Abstract #3009

Impact of sequence parameters on the sensitivity of DDE and DODE sequences to microscopic anisotropy

Andrada Ianuș¹, Ivana Drobnjak¹, Noam Shemesh², and Daniel C. Alexander¹

¹CMIC, University College London, London, United Kingdom, ²Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal

In the long mixing time regime, double-diffusion-encoding (DDE) sequences provide contrast capable of reflecting microscopic anisotropy, which may have added value for highly heterogeneous tissues such as the gray matter. Recently, double-oscillating-diffusion-encoding (DODE) sequences, which combine oscillating waveforms and varying gradient orientation, have been proposed to improve sensitivity to microscopic anisotropy. This work investigates the effect of varying different sequence parameters and shows that DODE sequences provide higher sensitivity to pore size for elongated pores, while DDE sequences are more sensitive to pore eccentricity.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.