Abstract #3011

Double-Pulsed-Field Gradient MRI in the Long Evans shaker rats' spinal cords

Debbie Anaby¹, Darya Morozov¹, Ian D. Duncan², and Yoram Cohen^1,3

¹School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel, ²Medical Sciences, The University of Wisconsin-Madison, Madison, WI, United States, ³Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

Double pulsed-field gradient (d-PFG) MRI has recently been suggested as an additional methodology for studying microstructure in the CNS. The Long Evans shaker (les) rats’ CNS has been previously studied by q-space diffusion (QSI) and more recently by angular d-PFG MRI. Here, we characterize the microstructure of the les spinal cords by fitting the angular d-PFG MRI data to the multiple correlation function (MCF) and extracting the unique parameter L/R ratio and its fractions. Clearly, the angular d-PFG methodology is capable of distinguishing between the les and their controls, in white matter and even in some gray matter ROIs.

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