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Abstract #3011

Double-Pulsed-Field Gradient MRI in the Long Evans shaker rats' spinal cords

Debbie Anaby1, Darya Morozov1, Ian D. Duncan2, and Yoram Cohen1,3

1School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel, 2Medical Sciences, The University of Wisconsin-Madison, Madison, WI, United States, 3Sagol School of Neurosciences, Tel Aviv University, Tel Aviv, Israel

Double pulsed-field gradient (d-PFG) MRI has recently been suggested as an additional methodology for studying microstructure in the CNS. The Long Evans shaker (les) rats’ CNS has been previously studied by q-space diffusion (QSI) and more recently by angular d-PFG MRI. Here, we characterize the microstructure of the les spinal cords by fitting the angular d-PFG MRI data to the multiple correlation function (MCF) and extracting the unique parameter L/R ratio and its fractions. Clearly, the angular d-PFG methodology is capable of distinguishing between the les and their controls, in white matter and even in some gray matter ROIs.

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