Abstract #3012

Effects of the Number of Diffusion Directions in Diffusion Kurtosis Imaging: a Structural Connectivity Study using in vivo data

Ricardo Loução¹, Karolina Elsner¹, Rita G. Nunes¹, Rafael Neto-Henriques², Marta Correia², André Ribeiro³, and Hugo Ferreira¹

¹Instituto de Biofísica e Engenharia Biomédica, Lisbon, Portugal, ²Cognition and Brain Science Unit, MRC, Cambridge, United Kingdom, ³Centre for Neuropsychopharmacology, London, United Kingdom

Diffusion Kurtosis Imaging Tractography Reconstructions (DKI-TR) are often performed using high quality data. In clinical practice, that is often not possible, as only a lower number of b-values and diffusion gradient directions can be acquired. This study assessed the performance of DKI-TR for the two algorithms currently proposed for DKI-TR using variable amounts of data, and looked at their respective structural connectivity metrics. A 64 gradient direction data set was acquired in six healthy subjects, and down-sampled to 21 and 32 directions. Differences were found between gradient sets and also between algorithms, regarding the reconstructions and the connectivity metrics.

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