Meeting Banner
Abstract #3018

A new framework for the optimisation of multi-shell diffusion weighting MRI settings using a parameterised Cramér-Rao lower-bound

Ezequiel Farrher1, Ivan I. Maximov2, Vincent Gras1, Farida Grinberg1,3, Rüdiger Stirnberg1,4, and N. Jon Shah1,3

1INM 4 - Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany, 2Experimental Physics III, TU Dortmund University, Dortmund, Germany, 3Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 4German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

We propose a parameterisation for multi-shell diffusion gradient settings which is sufficiently flexible to cover a broad range of experimental configurations, on the one hand, but uses only 6 degrees of freedom, on the other. Thus, such parameterisation enables a robust optimisation of the diffusion weighting settings by minimising the Cramér-Rao lower bound of the parameters of interest. Finally, we demonstrate its performance in the context of the biexponential diffusion tensor analysis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here