Abstract #3036

Reliable estimation of Diffusional kurtosis in the skeletal muscle needs perfusion correction.

Alberto De Luca^1,2,3, Alessandra Bertoldo¹, and Martijn Froeling³

¹Department of Information Engineering, University of Padova, Padova, Italy, ²Neuroimaging Lab, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini (LC), Italy, ³Department of Radiology, University Medical Center, Utrecht, Netherlands

Perfusion is known to affect the estimation of Diffusion Tensor Imaging (DTI) measures on the skeletal muscle. However, no previous works evaluated its effects on kurtosis estimation. Therefore, in this study we investigated the influence of perfusion on kurtosis. Synthetic signals for different perfusion levels with and without isotropic kurtosis were generated and then fitted with and without taking IVIM into consideration. Results showed that IVIM correction was essential to estimate non-biased values of kurtosis in case of increased perfusion. Real data showed that the simultaneous estimation of kurtosis and IVIM is robust and feasible.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.