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Abstract #3037

High field DTI and NODDI imaging to assess the effects of systemic inflammation on the pup rat brain.

Yohan van de Looij1,2, Justin M Dean3, Alistair J Gunn3, Petra S Hüppi1, and Stéphane V Sizonenko1

1Division of Child Growth & Development, Department of Pediatrics, University of Geneva, Geneva, Switzerland, 2Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Department of Physiology, University of Auckland, Auckland, New Zealand

Infection-induced inflammation is a major cause of injury to the white matter and grey matter structures of the brain in the early preterm infant. In the present study, we assessed the long-term effects of early-life inflammation on white and grey matter microstructure using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) at 9.4T. In this study, we characterized the microstructural consequences of LPS exposure in newborn pup rats recovered to P21. Mild changes in white matter and cortical development were observed without ventriculomegaly. DTI and NODDI can be used to assess subtle changes following LPS exposure.

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