Abstract #3037

High field DTI and NODDI imaging to assess the effects of systemic inflammation on the pup rat brain.

Yohan van de Looij^1,2, Justin M Dean³, Alistair J Gunn³, Petra S Hüppi¹, and Stéphane V Sizonenko¹

¹Division of Child Growth & Development, Department of Pediatrics, University of Geneva, Geneva, Switzerland, ²Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Department of Physiology, University of Auckland, Auckland, New Zealand

Infection-induced inflammation is a major cause of injury to the white matter and grey matter structures of the brain in the early preterm infant. In the present study, we assessed the long-term effects of early-life inflammation on white and grey matter microstructure using diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) at 9.4T. In this study, we characterized the microstructural consequences of LPS exposure in newborn pup rats recovered to P21. Mild changes in white matter and cortical development were observed without ventriculomegaly. DTI and NODDI can be used to assess subtle changes following LPS exposure.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.