Abstract #3042

Differentiating Contributions To Diffusional Kurtosis with Symmetrized Double-PFG MRI

Jeffrey Louis Paulsen¹, Iris Yuwen Zhou², Yi-Qiao Song¹, and Phillip Zhe Sun²

¹Schlummerger-Doll Research, Boston, MA, United States, ²Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States

Kurtosis imaging enables valuable diagnostics of stroke and other tissue pathologies. It can arise both directly from restricted diffusion, and indirectly from averaging multiple microscopic environments. We develop an EPI imaging sequence utilizing double diffusion contrast that isolates the direct contribution. We demonstrate consistency with traditional kurtosis imaging in phantoms yet unique contrast in-vivo in a live rat brain.

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