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Abstract #3043

Whole-body diffusion weighted imaging in multiple myeloma: Temporal changes of Gaussian and non-Gaussian diffusion parameters following treatment. Initial experience at 3.0T

Arash Latifoltojar1, Margaret Hall-Craggs2, Nikolaos Dikaios1, Kwee Yong1, Neil Rabin2, Alan Bainbridge2, Magdalena Sokolska2, and Shonit Punwani1

1University College London, London, United Kingdom, 2University College London Hospital, London, United Kingdom

Diffusion weighted imaging's apparent diffusion coeffiecient (ADC) has been shown to be a potential imaging biomarker for monitoring treatment response in multiple myeloma. However, in most instances, a mono- exponential fitting model is used to assess temporal changes. In this work, we investigated the Gaussian and non-Gaussian fitting algorithms and their respective quantitative biomarkers for assessing response in multiple myeloma using whole body diffusion weighted imaging.

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