Abstract #3060

Diffusion Tensor Imaging (DTI) of the myopathic and dystrophic skeletal muscle

Sarah Keller¹, Jerry Zhiyue Wang², Amir Golsari³, Adam Gerhard¹, Hendrick Kooijman⁴, Mathias Gelderblom³, and Jin Yamamura¹

¹Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany, ²Radiology, University of Texas Soutwestern Medical Center, Dallas, TX, United States, ³Neurology, University Medical Center Hamburg Eppendorf (UKE), Hamburg, Germany, ⁴MRI, Philips GmbH, Hamburg, Germany

MRI-Diffusion tensor imaging (DTI) based fiber tracking is an emerging tool for the evaluation of alterations in the skeletal muscle architecture caused by trauma and various inflammatory or hereditary diseases. It remains still a matter of debate, whether dystrophic conditions of the skeletal muscle, which are frequently associated with fatty infiltration, can be reliable assessed by DTI, as previous studies showed the potential biasing effect of the fat fraction (%FF) and the concomitant decrease of the signal to noise ratio (SNR) [1, 2]. The goal of this study was to analyze the DTI based apparent diffusion coefficient (ADC), fractional anisotropy (FA) and tractography data in various conditions of muscular disease, either with or without increase of the FF in comparison to healthy controls on a 3T system.

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