Abstract #3074

Cortico-Subcortical motor network integrity relates to functional recovery after stroke

Silvia Obertino¹, Lorenza Brusini¹, Ilaria Boscolo Galazzo^2,3, Mauro Zucchelli¹, Alessandro Daducci⁴, Gloria Menegaz¹, and Cristina Granziera^5,6

¹Computer Science, University of Verona, Verona, Italy, ²Institute of Nuclear Medicine, UCL, United Kingdom, ³Neuroradiology, University Hospital Verona, Italy, ⁴École polytechnique fédérale de Lausanne, Switzerland, ⁵Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Chalestown, MA, United States, ⁶Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland

In this work, we investigated whether the structural properties of cortico-subcortical (CS) motor circuits are related to motor outcome after stroke. To do this, we acquired Diffusion Spectrum Imaging data in 10 stroke patients at 3 time points after stroke. We then performed tractographic reconstruction and estimated a number of microstructural indices, derived from the 3D Simple Harmonic Oscillator based Reconstruction and Estimation (SHORE) model, in the cortico-subcortical motor fiber tracts. Linear regression analysis showed that that SHORE metrics of thalamo-cortical and intrastriatal connections in the first week after stroke are strongly related to stroke recovery at 6 months follow-up.

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