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Abstract #3074

Cortico-Subcortical motor network integrity relates to functional recovery after stroke

Silvia Obertino1, Lorenza Brusini1, Ilaria Boscolo Galazzo2,3, Mauro Zucchelli1, Alessandro Daducci4, Gloria Menegaz1, and Cristina Granziera5,6

1Computer Science, University of Verona, Verona, Italy, 2Institute of Nuclear Medicine, UCL, United Kingdom, 3Neuroradiology, University Hospital Verona, Italy, 4École polytechnique fédérale de Lausanne, Switzerland, 5Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Chalestown, MA, United States, 6Advanced Clinical Imaging Technology (HC CMEA SUI DI BM PI), Siemens Healthcare AG, Lausanne, Switzerland

In this work, we investigated whether the structural properties of cortico-subcortical (CS) motor circuits are related to motor outcome after stroke. To do this, we acquired Diffusion Spectrum Imaging data in 10 stroke patients at 3 time points after stroke. We then performed tractographic reconstruction and estimated a number of microstructural indices, derived from the 3D Simple Harmonic Oscillator based Reconstruction and Estimation (SHORE) model, in the cortico-subcortical motor fiber tracts. Linear regression analysis showed that that SHORE metrics of thalamo-cortical and intrastriatal connections in the first week after stroke are strongly related to stroke recovery at 6 months follow-up.

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