Abstract #3075

Comparisons of cortical depth dependence of diffusion properties over the whole human brain in-vivo

Oleg Posnansky¹, Myung-Ho In¹, and Oliver Speck¹

¹Department of Biomedical Magnetic Resonance, Institute of Experimental Physics, Magdeburg, Germany

Ultra-high field (≥7 T) magnetic resonance imaging possesses substantial sensitivity to depict patterns of tissue cytoarchitecture. Recent studies have shown a cortex depth dependence of diffusion tensor invariants such as fractional anisotropy and mean diffusivity. In this study we further probe the potential of diffusion tensor imaging for the whole human brain in vivo by mapping it on the segments of Desikan-Killiany atlas. Such analysis complied via very precise distortion correction procedure and building a series of lamellae, allows one to understand a spatial specificity of marginal distribution of diffusion tensor invariants and reveal unusual effects in fiber topology.

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