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Abstract #3081

Validation and comparison of diffusion MR methods measuring transcytolemmal water exchange rate

Xin Tian1,2, Hua Li1, Xiaoyu Jiang1, Jingping Xie1, John C Gore1, and Junzhong Xu1

1Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 2Radiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China, People's Republic of

Two diffusion-based method, the CG (constant gradient) and FEXI (filtered exchange imaging) methods, have been developed to provide a flexible and safer means to measure transcytolemmal water exchange rate $$$k_{in}$$$ non-invasively in vivo. However, neither methods have been fully validated up to date. In the present work, computer simulations and in vitro experiments with well-controlled cultured cells with different sizes and permeabilities were performed to evaluate the accuracy of the CG and FEXI methods. The results suggest that $$$k_{in}$$$ can be accurately estimated when $$$k_{in}$$$ < 10 Hz. Although the FEXI method provides less accurate results, the linear dependence of AXR on $$$k_{in}$$$ suggesting it is still a reliable method.

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