Abstract #3082

Metrics of microscopic anisotropy: a comparison study

Andrada Ianuș¹, Noam Shemesh², Daniel C. Alexander¹, and Ivana Drobnjak¹

¹CMIC, University College London, London, United Kingdom, ²Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal

Microscopic anisotropy disentangles the effects of pore shape from orientation distribution, and thus can serve as a valuable metric for underlying microstructural configurations. Recent developments in diffusion MRI proposed different approaches to acquire and analyse data for extracting information regarding microscopic anisotropy. This work compares in simulation two recently introduced metrics of microscopic anisotropy: fractional eccentricity (FE), derived from double-diffusion-encoding (DDE) sequences and microscopic fractional anisotropy (μFA), derived from a combination of sequences with isotropic and directional diffusion weighting. We find that DDE-derived metrics are more reliable for quantifying underlying microstructures if diffusion is restricted, while μFA is closer to the ground truth values when individual micro-domains feature Gaussian diffusion.

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