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Abstract #3083

Apparent Exchange Rate in Multi-compartment Anisotropic Tissue

Samo Lasič1, Sune N. Jespersen2,3, Henrik Lundell4, Markus Nilsson5, Tim B. Dyrby4, and Daniel Topgaard6

1CR Development, AB, Lund, Sweden, 2CFIN/MINDLab, Department of Clinical Medicine, Aarhus University, Arhus, Denmark, 3Department of Physics and Astronomy, Aarhus University, Arhus, Denmark, 4Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark, 5Lund University Bioimaging Center, Lund University, Lund, Sweden, 6Physical Chemistry, Lund University, Lund, Sweden

Filter exchange imaging (FEXI) is a noninvasive method to probe Apparent Exchange Rate (AXR). Understanding how diffusion anisotropy affects AXR is fundamental in experimental design and interpretation of results. In case of only two compartments, AXR is isotropic regardless of diffusion anisotropy. The key finding of this work is that AXR is anisotropic even in systems with a single exchange rate if there are more than two orientationally dispersed compartments. These findings may guide identification of different fiber populations and their directions and could be useful for analysis of fiber-specific characteristics.

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