Abstract #3090

Anomalous diffusion parameters are sensible to microstructural variations in brain due to aging

Michele Guerreri^1,2, Alessandra Caporale^1,2, Marco Palombo^1,3, Ivan De Berardinis¹, Emiliano Macaluso⁴, Marco Bozzali⁴, and Silvia Capuani¹

¹Department of physics, CNR ISC UOS Roma Sapienza, Rome, Italy, ²Department of anatomical, histological, forensic and of the locomotor system science, Morphogenesis & Tissue Homeostasis, Sapienza University, Rome, Italy, ³MIRCen, CEA/DSV/I2BM, Fontenay-Aux Roses, France, ⁴Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy

We investigated the anomalous diffusion (AD) stretched exponential γ-imaging model to overcome the sensitivity limitations of conventional DTI approach based on the assumption of the Gaussian model with regard of displacements of water molecules in tissues. The benefits of this approach are illustrated with an in-vivo diffusion study of the human brain performed on 18 healthy volunteers in the age range (23-70 years). Mean γ (Mγ) and anisotropic γ (Aγ) maps are obtained and compared with DTI maps. The current study suggests that Mγ and Aγ are more sensitive to micro-structural changes caused by normal aging, compared to DTI metrics.

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