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Abstract #3091

Diffusion Microstructure Imaging With High-Performance Head-Only Gradient: Preliminary Results

Ek T Tan1, Jonathan I Sperl2, Miguel Molina Romero2,3, Seung-Kyun Lee1, Matt A Bernstein4, and Thomas KF Foo1

1GE Global Research, Niskayuna, NY, United States, 2GE Global Research, Munich, Germany, 3Technical University of Munich, Munich, Germany, 4Mayo Clinic, Rochester, MN, United States

A high-performance head-only gradient coil (Gmax=80 mT/m, SR=700 T/m/s) allows diffusion imaging at substantially shorter echo-time and echo-spacing than conventional whole-body gradient coil systems. This greatly benefits microstructure imaging with diffusion EPI, providing reduced echo spacing by up-to two-fold and shorter TE by up-to 30%. Imaging results demonstrate reduced distortion and improved white matter SNR. Preliminary results on axonal radius mapping with high b-value imaging (up-to b=12,000 s/mm2) demonstrate the feasibility of 2 mm-isotropic imaging with the head-gradient.

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