Abstract #3112

Transmural heterogeneity of in-vivo whole heart diffusion parameters: architecture, physiology or artifact?

Martijn Froeling¹, Tim Leiner¹, Laura W M Vergoossen², Eibert A ten Hove², Aart J Nederveen³, Gustav J Strijkers⁴, and Peter R Luijten¹

¹Radiology, UMC Utrecht, Utrecht, Netherlands, ²Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, ³Radiology, AMC Amsterdam, Amsterdam, Netherlands, ⁴Biomedical Engineering & Physics, AMC Amsterdam, Amsterdam, Netherlands

A recent study by McGill et al. showed in-vivo spatial and transmural heterogeneity of cardiac diffusion parameters. The aim of this study was to investigate the origin of DWI-parameter heterogeneity using whole heart in- and ex-vivo SE-DWI. Based on our results, transmural heterogeneity is partially explained by variations in transmural and spatial perfusion signal fraction and, partially seems to have its origin in cardiac architecture during systole.

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