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Abstract #3112

Transmural heterogeneity of in-vivo whole heart diffusion parameters: architecture, physiology or artifact?

Martijn Froeling1, Tim Leiner1, Laura W M Vergoossen2, Eibert A ten Hove2, Aart J Nederveen3, Gustav J Strijkers4, and Peter R Luijten1

1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 3Radiology, AMC Amsterdam, Amsterdam, Netherlands, 4Biomedical Engineering & Physics, AMC Amsterdam, Amsterdam, Netherlands

A recent study by McGill et al. showed in-vivo spatial and transmural heterogeneity of cardiac diffusion parameters. The aim of this study was to investigate the origin of DWI-parameter heterogeneity using whole heart in- and ex-vivo SE-DWI. Based on our results, transmural heterogeneity is partially explained by variations in transmural and spatial perfusion signal fraction and, partially seems to have its origin in cardiac architecture during systole.

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