Abstract #3118

Mapping Dynamic Myocardial Fibre Reorientation in Dilated Cardiomyopathy using Dual-Phase In-Vivo Cardiac Diffusion Tensor Imaging

Constantin von Deuster^1,2, Eva Sammut¹, Christian T. Stoeck^1,2, Reza Razavi¹, and Sebastian Kozerke^1,2

¹Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, ²Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

In vivo cardiac diffusion tensor imaging (DTI) was employed to study dynamic alterations of myocardial microstructure in patients with dilated cardiomyopathy (DCM) relative to healthy controls using dual-phase cardiac DTI. A reduction in dynamic change of fiber orientation between diastole and systole compared to the controls was observed. Steeper diastolic helix angles in DCM patients relative to controls were associated with a larger pre-stretch of the left ventricle. It is speculated that this larger pre-stretch alongside with reduced myocyte shortening compromises the ability to dynamically reorient fiber aggregates during systolic contraction.

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