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Abstract #3125

Myocardial Strain Analysis With CMR in Breast Cancer Patients with Iatrogenic Cardiotoxicity Using Heart Deformation Analysis: Comparison to DENSE

Abraham Bogachkov1, Kai Lin2, Ahmadreza Ghasemiesfe2, Amir Ali Rahsepar3, Bruce Spottiswoode3, Ben Freed4, Michael Markl2, James Carr2, and Jeremy Collins2

1Northwestern University Feinberg School of Medicine, Chicago, IL, United States, 2Radiology, Northwestern University, Chicago, IL, United States, 3Cardiovascular MR R&D, Siemens Healthcare, Chicago, IL, United States, 4Cardiology, Northwestern University, Chicago, IL, United States

Strain imaging at cardiac MR has been shown to be a powerful tool in the pre-clinical detection of early cardiac dysfunction in the heart failure population, but has been only minimally studied in cardiotoxicity patients. This study evaluated a semi-automatic heart deformation analysis (HDA) tool in the assessment of left ventricular myocardial strain in patients with known cardiotoxicity, and found very good to excellent agreement with global strain values calculated using displacement encoding with stimulated echoes (DENSE). HDA analysis of conventional cine sequences has the potential to play a significant role in the evaluation of patients at risk for cardiotoxicity.

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