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Abstract #3128

Peak Filling Rates assessed by Cardiac Magnetic Resonance Imaging indicate Diastolic Dysfunction from Myocardial Iron Toxicity

Jin Yamamura1, Sarah Keller1, Roland Fischer2,3, Regine Grosse4, Gregory Kurio3, Gunnar Lund1, Joachim Graessner5, Gerhard Adam1, and Bjoern Schoennagel1

1Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 2Biochemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3Department of Radiology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, United States, 4Department of Pediatric Hematology/Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 5Siemens Healthcare, Hamburg, Germany

The diastolic peak filling rate ratio (PFRR) is a sensitive marker to indicate diastolic dysfunction from myocardial iron toxicity in patients with systemic iron overload disease. Precise assessment of the PFRR by CMR requires a volumetric approach with exclusion of trabeculae and papillary muscles from the LV cavity. The PFRR assessed by CMR may be a valuable parameter for the screening and monitoring of myocardial iron toxicity due to iron deposition in patients with preserved systolic function.

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