Abstract #3128

Peak Filling Rates assessed by Cardiac Magnetic Resonance Imaging indicate Diastolic Dysfunction from Myocardial Iron Toxicity

Jin Yamamura¹, Sarah Keller¹, Roland Fischer^2,3, Regine Grosse⁴, Gregory Kurio³, Gunnar Lund¹, Joachim Graessner⁵, Gerhard Adam¹, and Bjoern Schoennagel¹

¹Diagnostic and Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ²Biochemistry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ³Department of Radiology, UCSF Benioff Children's Hospital Oakland, Oakland, CA, United States, ⁴Department of Pediatric Hematology/Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ⁵Siemens Healthcare, Hamburg, Germany

The diastolic peak filling rate ratio (PFRR) is a sensitive marker to indicate diastolic dysfunction from myocardial iron toxicity in patients with systemic iron overload disease. Precise assessment of the PFRR by CMR requires a volumetric approach with exclusion of trabeculae and papillary muscles from the LV cavity. The PFRR assessed by CMR may be a valuable parameter for the screening and monitoring of myocardial iron toxicity due to iron deposition in patients with preserved systolic function.

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