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Abstract #3137

A data analysis framework to study remodeling after myocardial infarction

Freddy Odille1,2,3, Lin Zhang1,2, Bailiang Chen1,2,3, Jacques Felblinger1,2,3,4,5, Damien Mandry1,2,4, and Marine Beaumont3,5

1U947, Inserm, Nancy, France, 2IADI, Université de Lorraine, Nancy, France, 3CIC-IT 1433, Inserm, Nancy, France, 4Pôle imagerie, CHRU de Nancy, Nancy, France, 5Pôle S2R, CHRU de Nancy, Nancy, France

A data analysis framework is proposed to study the relation between scar severity and regional myocardial function during the process of remodeling after acute myocardial infarction (MI). The framework includes registration steps to correct for slice-to-slice inconsistencies, to align cine with late gadolinium enhancement (LGE) data and to align data from follow-up scans. The framework was evaluated in 114 patients with CMR scans within 3 days after MI and at 6 months. Registration accuracy was below 3 mm. Results show that function at 6 months was inversely associated with scar transmuraltiy at both 3 days and 6 months.

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