Abstract #3138

High-resolution MR Imaging of Left-ventricular Function in Newborn Mice

Mahon L Maguire¹, Mala Rohling², Megan Masters², Debra McAndrew¹, Paul Riley², and Jurgen E Schneider¹

¹Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ²Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom

The neonatal mouse heart has been reported to regenerate following myocardial injury during the first days of life. Research into this regenerative capability is being actively pursued for translation into the clinic. This study presents cardiac cine imaging of one-day old mice using retrospectively gated, accelerated MR imaging with recovery. Images were acquired with 78x78x500 μm resolution. Left ventricular functional parameters were derived from the images and are presented. This proof of concept study demonstrates that cardiac functional MR imaging with recovery in newborn mice is practical. It also allows the investigation of myocardial regeneration during the first days of life.

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