Abstract #3150

Cardiac Tissue Characterization in End Stage Renal Disease Patients with Non-Contrast MRI and Myocardial Mechanics

Tori A Stromp^1,2, Joshua C Kaine^2,3, Tyler J Spear², Kristin N Andres^2,3, Brandon K Fornwalt⁴, Vincent L Sorrell⁵, Steve W Leung⁵, and Moriel H Vandsburger^1,2,6

¹Department of Physiology, University of Kentucky, Lexington, KY, United States, ²Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, United States, ³College of Medicine, University of Kentucky, Lexington, KY, United States, ⁴Institute for Advanced Application, Geisinger Health System, Danville, PA, United States, ⁵Gill Heart Institue, University of Kentucky, Lexington, KY, United States, ⁶Biomedical Engineering, University of Kentucky, Lexington, KY, United States

Patients with end stage renal disease (ESRD) suffer from high rates of sudden cardiac death, often attributed to development of reactive fibrosis. This study aims to integrate cardiac tissue characterization via non-contrast 2-pt bSSFP with myocardial mechanical analysis. ESRD patients demonstrate elevated myocardial signal with magnetization transfer-weighted 2-pt bSSFP, indicating increased fibrosis. This elevated signal correlates with delayed time to peak contraction and septo-lateral dyssynchrony, which are both elevated in ESRD patients. Combining non-contrast 2-pt bSSFP for tissue characterization with analysis of regional contractile function offers a promising approach to identify potential MRI biomarkers of cardiac risk in ESRD.

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