Abstract #3153

Free-breathing SASHA T1 mapping using high-contrast image registration has greater precision than MOLLI T1 mapping

Kelvin Chow¹, Yang Yang², and Michael Salerno^1,2

¹Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA, United States, ²Biomedical Engineering, University of Virginia, Charlottesville, VA, United States

The robustness of SASHA T1 mapping to systematic errors provides more accurate T1 measurements, but SASHA is less precise than the more commonly used MOLLI sequence. Free-breathing SASHA acquisitions can increase precision in T1 maps, but motion correction of SASHA images is challenging due to poor blood-tissue contrast. We present a novel approach for robust image registration by acquiring additional high-contrast data in a keyhole fashion without affecting T1 accuracy. In 10 healthy subjects, a SASHA T1 maps acquired in <90 seconds of free-breathing had a lower myocardial T1 standard deviation than MOLLI (46.1±3.8 ms vs. 55.3±7.7 ms, p<0.05).

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