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Abstract #3154

Sensitive Non-contrast CMR Index for Quantifying Myocardial Fibrosis

Jiayu Sun1, Simeng Wang1, Robert O'Connor2, David Muccigrosso3, Yucheng Chen4, Wei Cheng1, Charles Hildebolt3, Fabao Gao1, and Jie Zheng3

1Radiology, West Hospital, Chengdu, China, People's Republic of, 2NIH, Bethesda, MD, United States, 3Radiology, Washington University in St. Louis, St. Louis, MO, United States, 4Cardiology, West Hospital, Chengdu, China, People's Republic of

The purpose is to develop and evaluate a non-contrast CMR approach for sensitive and quantitative assessment of myocardial fibrosis. Ten patients with cardiomyopathy were scanned with and without contrast injection. A quantitative fibrosis index derived from native T1ρ dispersion contrast was obtained and compared with extracellular volume calculated by T1 mapping. A strong correlation was shown between two indexes and superior sensitivity was observed for fibrosis index to detect myocardial diffuse fibrosis.

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