Abstract #3154

Sensitive Non-contrast CMR Index for Quantifying Myocardial Fibrosis

Jiayu Sun¹, Simeng Wang¹, Robert O'Connor², David Muccigrosso³, Yucheng Chen⁴, Wei Cheng¹, Charles Hildebolt³, Fabao Gao¹, and Jie Zheng³

¹Radiology, West Hospital, Chengdu, China, People's Republic of, ²NIH, Bethesda, MD, United States, ³Radiology, Washington University in St. Louis, St. Louis, MO, United States, ⁴Cardiology, West Hospital, Chengdu, China, People's Republic of

The purpose is to develop and evaluate a non-contrast CMR approach for sensitive and quantitative assessment of myocardial fibrosis. Ten patients with cardiomyopathy were scanned with and without contrast injection. A quantitative fibrosis index derived from native T1ρ dispersion contrast was obtained and compared with extracellular volume calculated by T1 mapping. A strong correlation was shown between two indexes and superior sensitivity was observed for fibrosis index to detect myocardial diffuse fibrosis.

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