Abstract #3157

Native myocardial T1 correlates with right ventricular mass and invasive catheter measurement in patients with Pulmonary Hypertension

Laura Claire Saunders¹, Neil J Stewart¹, Charlotte Hammerton¹, David Capener¹, Valentina O Puntmann², David G Kiely³, Martin J Graves⁴, Andy Swift¹, Jim M Wild¹, and Laura Claire Saunders¹

¹Academic Unit of Radiology, The University of Sheffield, Sheffield, United Kingdom, ²Department of Cardiovascular Imaging, Kings College London, London, United Kingdom, ³The University of Sheffield, Sheffield, United Kingdom, ⁴University of Cambridge School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom

Patients with pulmonary hypertension (n=102, 58±16 years, 56% female) and age and sex matched volunteers (n=34, 51±14 years, 58% female) underwent functional cardiac MR and MOLLI T1 mapping at 1.5T. MOLLI images were registered to correct for respiratory motion. Patients had elevated myocardial T1 at the right ventricular (RV) insertion point (p<0.001) and left ventricular free wall when compared to healthy volunteers (p=0.013). RV insertion point T1 and pulmonary artery pressure correlated significantly (r=0.406 p=0.016). Correlations were found between RV free wall and septal T1 and diastolic mass index (corrected for age and sex) (r=0.305, p=0.003 and r=0.281, p=0.006 respectively). Patients with pulmonary hypertension (n=102, 58±16 years, 56% female) and age and sex matched volunteers (n=34, 51±14 years, 58% female) underwent functional cardiac MR and MOLLI T1 mapping at 1.5T. MOLLI images were registered to correct for respiratory motion. Patients had elevated myocardial T1 at the right ventricular (RV) insertion point (p<0.001) and left ventricular free wall when compared to healthy volunteers (p=0.013). RV insertion point T1 and pulmonary artery pressure correlated significantly (r=0.406 p=0.016). Correlations were found between RV free wall and septal T1 and RV mass index (corrected for age and sex) (r=0.305, p=0.003 and r=0.281, p=0.006 respectively).

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