Abstract #3172

Frequency Shift Imaging (FSI) for characterization of cells labeled with superparamagnetic iron-oxide nanoparticles

Judy Alper^1,2, Priti Balchandani¹, Francois Fay¹, and Hadrien Dyvorne¹

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Biomedical Engineering, City College of New York, New York, NY, United States

MRI has long been used as a detection tool for cells labeled with superparamagnetic iron-oxide nanoparticles (SPIOs). Positive contrast imaging of off-resonance SPIO signal provides benefits over negative contrast methods and imaging the SPIOs at 7 Tesla (7T) allows for leveraging greater off-resonance sensitivity for quantitative imaging of smaller cell populations. In this study, we imaged a cell phantom containing SPIO labeled macrophages at 7T. We demonstrated the performance of frequency shift imaging (FSI), a new acquisition technique, for characterizing the magnetic signature of SPIOs, as compared to negative contrast methods.

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