Abstract #3280

Characterization of Brown Adipose Tissue using Multi-Varying-Peak MR Spectroscopy (MVP-MRS)

Gregory Simchick¹, Jinjian Wu², Guangming Shi², Hang Yin³, and Qun Zhao¹

¹Bioimaging Research Center, University of Georgia, Athens, GA, United States, ²Xidian University, Xian, China, People's Republic of, ³Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, United States

Differentiation of brown adipose tissue (BAT) from white adipose tissue (WAT) using magnetic resonance imaging (MRI) is clinically important to treat obesity, diabetes and heart disease. In contrast to the traditional Dixon model of single fat- and water-peak or fixed multi-fat-peak models, we propose a Multi-Varying-Peaks MR Spectroscopic (MVP-MRS) model, based on MR imaging data acquired with multiple echoes, to better characterize chemical structures of the fatty acid (saturated vs. unsaturated). Compared with traditional classification of BAT and WAT using fat fraction or proton relaxation time, the proposed MVP-MRS model can achieve a correct classification rate of 95% between BAT and WAT for in vivo mouse data implying great potentials in future longitudinal imaging of BAT and WAT.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.