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Abstract #3285

Robust in vivo DTI by Spatiotemporal Encoding

Eddy Solomon1, Gilad Liberman1, Noam Nissan2, and Lucio Frydman1

1Chemical Physics Department, Weizmann Institute of Science, Rehovot, Israel, 2Biological Regulation Department, Weizmann Institute of Science, Rehovot, Israel

A recently proposed single-shot MRI methodology, SPatio-temporal ENcoding (SPEN), was evaluated for its usefulness in DTI experiments. SPEN’s direct image acquisition is not bound by k-space sampling criteria, thereby enabling the use of stronger gradients during its monitoring of the low-bandwidth dimension. This helps it to overcome image distortions arising from field inhomogeneities, eddy currents and heterogeneous chemical environments. Single-shot and interleaved DTI SPEN measurements were tested under various pre-clinical and clinical settings, and the formalism needed to extract reliable DTI maps from SPEN data was derived. Substantial advantages in terms of overcoming EPI distortions were observed.

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