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Abstract #3286

Precision and Accuracy of Multi-Echo Based T2 mapping: Fitted vs Measured B1

Christopher L Lankford1 and Mark D Does1,2

1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Electrical Engineering, Vanderbilt University, Nashville, TN, United States

This abstract provides a simple criterion by which to determine whether refocusing pulse flip angle should be fitted or constrained to a measured B1+ map in multiple spin echo (MSE) based T2 mapping protocols. Using propagation of error theory including the Cramér-Rao lower bound, it was discovered that T2 estimate precision is improved through constraint when the signal-to-noise ratio (SNR) of the B1+ map is at least one-half the SNR of the MSE measurement. The accuracy cost of constraint is also evaluated and presented.

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