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Abstract #3294

Influence of multi-compartment effects on T2 mapping using multiecho steady state imaging

Dian Liu1, Andreas Steingoetter1,2, Jelena Curcic1,2, and Sebastian Kozerke1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland

Dual and triple echo steady state (DESS and TESS) schemes have enabled rapid measurements of transverse relaxation times (T2). However, it has been shown that TESS may result in errorneous T2 values when applied to articular cartilage. Since cartilage is a multi-compartment tissue, chemical shift-related signal fluctuations in the TESS echo modes need to be considered. The purpose of this work was to investigate the accuracy of T2 quantification of multi-compartmental tissue using DESS and TESS based on computer simulations, in vitro and in vivo measurements. Results show that multi-compartment effects can significantly limit the accuracy of T2 quantification and hence require careful attention.

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