Abstract #3294

Influence of multi-compartment effects on T2 mapping using multiecho steady state imaging

Dian Liu¹, Andreas Steingoetter^1,2, Jelena Curcic^1,2, and Sebastian Kozerke¹

¹Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ²Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland

Dual and triple echo steady state (DESS and TESS) schemes have enabled rapid measurements of transverse relaxation times (T₂). However, it has been shown that TESS may result in errorneous T₂ values when applied to articular cartilage. Since cartilage is a multi-compartment tissue, chemical shift-related signal fluctuations in the TESS echo modes need to be considered. The purpose of this work was to investigate the accuracy of T₂ quantification of multi-compartmental tissue using DESS and TESS based on computer simulations, in vitro and in vivo measurements. Results show that multi-compartment effects can significantly limit the accuracy of T₂ quantification and hence require careful attention.

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