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Abstract #3293

Bloch-Siegert B1-mapping Improves Accuracy and Precision of T1 Measurements in the Breast at 3T

Jennifer G Whisenant1, Richard D Dortch1, Lori A Arlinghaus1, William A Grissom1, Hakmook Kang1, and Thomas E Yankeelov1

1Vanderbilt, Nashville, TN, United States

This study evaluated the ability of Bloch-Siegert B1 mapping to improve the accuracy and precision of variable flip angle (VFA)-derived T1 measurements of the breast at 3.0 T. Accuracy was evaluated by comparing VFA T1 values to inversion recovery measurements in a cohort of 16 healthy women. A reproducibility analysis from test-retest sessions within the same cohort was used to evaluate precision. After Bloch-Siegert B1 correction, accuracy of T1 measurements in the fat and fibroglandular tissue improved and measurement variability decreased. Thus, these results suggest that Bloch-Siegert B1 mapping is an attractive correction method for quickly obtaining accurate and precise measurements of T1 values of the breast at 3.0 T.

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