Abstract #3299

Method to Simultaneously Calibrate Flip Angles and Measure T1 of Hyperpolarized Gas during a Single Breath-hold

Jianping Zhong^1,2, Weiwei Ruan¹, Xianping Sun¹, Chaohui Ye^1,2, and Xin Zhou¹

¹State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Chinese Acad Sci, Wuhan, China, People's Republic of, ²School of Physics, Huazhong University of Science and Technology, Wuhan, China, People's Republic of

In hyperpolarized gas MRI, the accurate flip angle calibration and T₁ measurements are important. Traditional flip angle calibration methods are time-consuming and suffer from polarization losses during T₁ relaxation. In this study, we propose a method to simultaneously calibrate flip angles and measure T₁ in vivo during a breath-hold time of less than 4 seconds. The so-called single-breath method is magnitude based and simple to use. We demonstrate the accuracy of this method and contrast it with traditional methods. The results of the calibration verified that it is robust and repeatable.

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