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Abstract #3299

Method to Simultaneously Calibrate Flip Angles and Measure T1 of Hyperpolarized Gas during a Single Breath-hold

Jianping Zhong1,2, Weiwei Ruan1, Xianping Sun1, Chaohui Ye1,2, and Xin Zhou1

1State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Chinese Acad Sci, Wuhan, China, People's Republic of, 2School of Physics, Huazhong University of Science and Technology, Wuhan, China, People's Republic of

In hyperpolarized gas MRI, the accurate flip angle calibration and T1 measurements are important. Traditional flip angle calibration methods are time-consuming and suffer from polarization losses during T1 relaxation. In this study, we propose a method to simultaneously calibrate flip angles and measure T1 in vivo during a breath-hold time of less than 4 seconds. The so-called single-breath method is magnitude based and simple to use. We demonstrate the accuracy of this method and contrast it with traditional methods. The results of the calibration verified that it is robust and repeatable.

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