Abstract #3300

2D Constrained Point-Spread-Function in Magnetic Resonance Spectroscopic Imaging of Prostate

Shelley HuaLei Zhang¹, Jr-Yuan George Chiou¹, Robert Vincent Mulkern¹, Pelin Aksit Ciris², Stephan Maier¹, and Lawrence Panych¹

¹Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Department of Biomedical Engineering, Akdeniz University, Antalya, Turkey

Magnetic resonance spectroscopic imaging (MRSI) technique is often plagued by signal contamination (e.g. from fat) from outside the tissue of interest, particularly near organ boundaries. The goal is to demonstrate and validate in phantoms and healthy volunteers a spatial localization technique that features localized signal excitation and therefore eliminates the need for post-processing filtering. Here we demonstrated superior PSF’s at prostate-relevant metabolic peaks for a 2D Gaussian-based PSF-Choice encoding scheme. The reduction of contamination from signals in surrounding tissue was further demonstrated in an in-vitro phantom. The feasibility of the method was demonstrated in a small group of prostate MRSI studies with normal volunteers.

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