Abstract #3320

Cerebral Tissue Characterization by Magnetic Resonance Elastography and Arterial Spin Labeling

Patric Birr¹, Andreas Fehlner², Sebastian Hirsch², Florian Dittmann², Jing Guo², Jürgen Braun², Ingolf Sack², and Stefan Hetzer³

¹Physics, Humboldt University Berlin, Berlin, Germany, ²Radiology, Charité - University Medicine Berlin, Berlin, Germany, ³Berlin Center for Advanced Neuroimaging, Berlin, Germany

Two imaging modalities, magnetic resonance elastography (MRE) and arterial spin labeling (ASL), were used to compare mechanical properties of brain tissue with regional perfusion across subcortical brain regions. An inverse correlation of stiffness (|G*|) and average perfusion (CBF) was observed in deep gray matter when accounting for structurally and functionally distinct areas. In the |G*|-CBF space, globus pallidus, hippocampus, thalamus and amygdala clearly clustered from putamen and nucleus accumbens highlighting their anatomical differences in network density and vasculature. Differences in the microstructure between the striatum and other analyzed regions are not apparent by MRE or ASL alone.

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