Abstract #3319

Motor Learning Induced Neuroplasticity, Revealed By fMRI-Guided Diffusion Imaging

Lee Bremner Reid¹, Martin V Sale², Ross Cunnington^2,3, and Stephen E Rose¹

¹e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, Australia, ²Queensland Brain Institute, The University of Queensland, Brisbane, Australia, ³School of Psychology, The University of Queensland, Brisbane, Australia

Detecting neuroplasticity requires highly sensitive measurements that may be outside the bounds of standard parcellation-seeded tractography. Earlier attempts to measure neuroplasticity induced by motor learning have utilised voxelwise analyses. Such analyses are reliant on precise registration, can have low statistical power, and provide little certainty as to the functional relevance of areas of detected change. We have measured motor-learning-induced neuroplasticity along corticomotor and thalamocortical tracts using fMRI-seeded diffusion-MRI, finding that changes uniquely occur in the corticomotor tract. Unlike previous analyses, we reveal that these changes occur throughout the corticomotor tract, not just near the grey-/white-matter interface.

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