Abstract #3328

Effect of Gabapentin Administration on GABA and BOLD Signal in Visual Cortex of Healthy Men and Women

Ravi Prakash Reddy Nanga^1,2, Kosha Ruparel², Dina Appleby², Mark Elliott¹, Hari Hariharan¹, Ravinder Reddy¹, and Neill C Epperson^2,3,4,5

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ³Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ⁴Penn Center for the Study of Sex and Gender in Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ⁵Penn Center for Women’s Behavioral Wellness, Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States

We explored the potential for sex differences in brain Gamma-aminobutyric acid (GABA), glutamate (Glut) and neural response to an acute dose of gabapentin by using proton magnetic resonance spectroscopy (¹H-MRS) followed by functional magnetic resonance imaging (fMRI) at 7T.

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