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Abstract #3328

Effect of Gabapentin Administration on GABA and BOLD Signal in Visual Cortex of Healthy Men and Women

Ravi Prakash Reddy Nanga1,2, Kosha Ruparel2, Dina Appleby2, Mark Elliott1, Hari Hariharan1, Ravinder Reddy1, and Neill C Epperson2,3,4,5

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 3Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 4Penn Center for the Study of Sex and Gender in Health, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, 5Penn Center for Women’s Behavioral Wellness, Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States

We explored the potential for sex differences in brain Gamma-aminobutyric acid (GABA), glutamate (Glut) and neural response to an acute dose of gabapentin by using proton magnetic resonance spectroscopy (1H-MRS) followed by functional magnetic resonance imaging (fMRI) at 7T.

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