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Abstract #3329

Brain volume changes during hypercapnia: Volume Reactivity

Jeroen C.W. Siero1, Jeroen H.J. de Bresser1, Lisa van der Kleij1, Jill B. de Vis1, and Jeroen Hendrikse1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands

Here we investigate brain volume changes upon a vasodilatory hypercapnic stimulus as a potential alternative to obtain cerebral tissue reactivity information. Using relatively standard 3D T1-weighted scans (MP-RAGE) and segmentation software we show significant volume changes (in all subjects) in subcortical deep gray matter areas which were paralleled by decreases in ventricular volume. This approach (volume reactivity) could yield novel insights on cerebral tissue reactivity in healthy and disease and be a potential alternative in cases where BOLD or ASL CVR interpretation can be ambiguous.

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