Abstract #3338

Acute effects of caffeine on grey matter haemodynamics

Alberto Merola¹, Esther AH Warnert¹, Michael A Germuska¹, Sharmila Khot^1,2, Daniel Helme², Lewys Richmond², Kevin Murphy¹, and Richard G Wise¹

¹CUBRIC, Cardiff University, Cardiff, United Kingdom, ²Department of Anesthesia and Intensive Care Medicine, Cardiff University, Cardiff, United Kingdom

The acute effects of caffeine on haemodynamics are not well characterized across the brain with MRI. We aim at measuring these in a double-blind, crossover, placebo-controlled study on sixteen healthy, moderate caffeine consumers using mTI PASL acquisitions and a two-compartment ASL model. Results show spatial variations in the CBF and TAT response across grey matter at different levels of resolution (grey matter, ROI and voxel), with the latter presenting mixed directions. Moreover we demonstrate that great attention must be paid to physiological assumptions when modelling ASL data to estimate CBF in studies on drugs that affect brain haemodynamics.

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