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Abstract #3339

Blood flow velocity and pulsatility in perforating arteries of cerebral white matter during hypercapnia

Lennart Geurts1, Alex Bhogal1, Jeroen C.W. Siero1, Peter R. Luijten1, and Jaco J.M. Zwanenburg1

1Radiology, UMCU, Utrecht, Netherlands

An increased blood flow pulsatility index in large cerebral arteries is a prognostic factor in stroke and has been linked to small vessel disease. Along with increased pulsatility, these patients show decreased hypercapnia induced cerebrovascular reactivity. We hypothesize that dilated vessels lose their ability to stretch and passively dampen the pulse pressure wave. The aim of this study was to shed light on how autoregulation influences the damping of the pulse pressure wave in small vessels. Our approach was to measure blood flow velocity and pulsatility changes in the perforating arteries of the white matter, during a hypercapnic breathing challenge.

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