Arjan D. Hendriks1, Natalia Petridou1, Catalina S. Arteaga de Castro1, Mark W.J.M. Gosselink1, Alessio Fracasso1, and Dennis W.J. Klomp1
By maximizing acquisition volume, using efficient semi
LASER detection with editing and macro molecular nulling, GABA can be detected
at high SNR within 3 minutes. GABA concentrations were measured in the visual
cortex and in a phantom containing a known concentration of GABA. A
bootstrapping method was used to determine the accuracy.
The results indicate that the stability and fitting
accuracy of the method is sufficient to detect concentration changes of GABA
higher than 3% within a short scan time of less than 3 minutes. In resting
state, GABA fluctuations up to 30% are found in in-vivo brain measurements.