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Abstract #3340

Pushing the limits of speed and accuracy for 7T GABA MR spectroscopy to reveal GABA level fluctuations in resting brain

Arjan D. Hendriks1, Natalia Petridou1, Catalina S. Arteaga de Castro1, Mark W.J.M. Gosselink1, Alessio Fracasso1, and Dennis W.J. Klomp1

1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands

By maximizing acquisition volume, using efficient semi LASER detection with editing and macro molecular nulling, GABA can be detected at high SNR within 3 minutes. GABA concentrations were measured in the visual cortex and in a phantom containing a known concentration of GABA. A bootstrapping method was used to determine the accuracy. The results indicate that the stability and fitting accuracy of the method is sufficient to detect concentration changes of GABA higher than 3% within a short scan time of less than 3 minutes. In resting state, GABA fluctuations up to 30% are found in in-vivo brain measurements.

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