Abstract #3341

Metabolic changes in the activated human visual cortex during mild hypoxia

Felipe Barreto^1,2, Nicholas Evanoff³, Donald Dengel³, Petr Bednarik^1,4,5, Ivan Tkac¹, Lynn Eberly⁶, Carlos Salmon², and Silvia Mangia¹

¹CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Department of Physics, University of Sao Paulo, Ribeirao Preto, Brazil, ³School of Kinesiology, University of Minnesota, Minneapolis, MN, United States, ⁴Central European Institute of Technology, Masaryk University, Brno, Czech Republic, ⁵Department of Medicine, University of Minnesota, Minneapolis, MN, United States, ⁶Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States

Previous fMRI studies have demonstrated reduced evoked vascular responses during mild hypoxia, which might indicate smaller neuronal recruitment during activation. Here we used fMRS at 7T to quantify the effects of mild hypoxia on stimulus-induced metabolic changes during visual stimulation. Our preliminary findings obtained on 6 healthy volunteers show that mild hypoxia does not result in detectable differences of functional metabolic changes as compared to normoxia, consistent with similar functional energy demands in both conditions. Together with previous fMRI findings, our results suggest that mild hypoxia alters the neurovascular coupling, but does not result in smaller neuronal recruitment during activation.

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