Meeting Banner
Abstract #3341

Metabolic changes in the activated human visual cortex during mild hypoxia

Felipe Barreto1,2, Nicholas Evanoff3, Donald Dengel3, Petr Bednarik1,4,5, Ivan Tkac1, Lynn Eberly6, Carlos Salmon2, and Silvia Mangia1

1CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Department of Physics, University of Sao Paulo, Ribeirao Preto, Brazil, 3School of Kinesiology, University of Minnesota, Minneapolis, MN, United States, 4Central European Institute of Technology, Masaryk University, Brno, Czech Republic, 5Department of Medicine, University of Minnesota, Minneapolis, MN, United States, 6Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States

Previous fMRI studies have demonstrated reduced evoked vascular responses during mild hypoxia, which might indicate smaller neuronal recruitment during activation. Here we used fMRS at 7T to quantify the effects of mild hypoxia on stimulus-induced metabolic changes during visual stimulation. Our preliminary findings obtained on 6 healthy volunteers show that mild hypoxia does not result in detectable differences of functional metabolic changes as compared to normoxia, consistent with similar functional energy demands in both conditions. Together with previous fMRI findings, our results suggest that mild hypoxia alters the neurovascular coupling, but does not result in smaller neuronal recruitment during activation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here