Abstract #3342

Quantification and normalization of Cerebral Blood Flow in rat brain using Pseudo-continuous Arterial Spin Labeling with phase-contrast-based flow measurement at 7 Tesla.

Sankar Seramani¹, Xuan Vinh To¹, Sakthivel Sekar¹, Boominathan Ramasamy¹, Kishore Bhakoo¹, and Kuan Jin Lee¹

¹Singapore Bioimaging Consortium, Singapore, Singapore

pCASL is a modified form of CASL where a short train of RF pulses reproduces CASL. pCASL sequence uses flow driven adiabatic pulses to invert the spin. The labeling efficiency of the pCASL sequence has a dependency on the velocity of the blood at the labeling. Phase contrast MRI (PCMRI) was used to measure the velocity of the blood at the labeling plane and to normalize the CBF value. In this study, we tested pCASL and PCMRI acquisition on a cohort of control rats vs. hyperglycemic rats and documented effect of varied labeling efficiency.

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