Abstract #3349

High-Speed Whole-Brain Oximetry with a Golden-Angle Radial Imaging Sequence

Wen Cao¹, Yulin Chang¹, Suliman Barhoum¹, Zachary B Rodgers¹, Michael C Langham¹, Erin K Englund¹, and Felix W Wehrli¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

The OxFlow imaging approach allows simultaneous quantification of whole-brain venous oxygen saturation and total cerebral blood flow for the cerebral metabolic rate of oxygen. However, the current Cartesian rendition of the sequence is not ideal as the achievable temporal resolution is limited and needs to be chosen upfront. Here, we designed a golden-angle radial (GAR) encoding sequence that yields an effective temporal resolution of 1.29s and evaluated it in six subjects who underwent a paradigm of repeated breath-holds. Good agreement exists between the two methods but GAR provided superior SNR and better delineation of the temporal dynamics during the stimulus.

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