Cerebrovascular reactivity measured with quantitative susceptibility mapping and TRUST MRI under hypercapnia
Jean-Christophe Brisset1, Olga Marshall1, Louise E Pape1, Hanzhang Lu2, and Yulin Ge1
1Radiology, New York University School of Medicine, New York, NY, United States, 2Radiology, Johns Hopkins University, Baltimore, MD, United States
Cerebrovascular reactivity (CVR) measures the
capacity of regulation of blood flow in response to vasoactive stimuli (e.g.,
CO2) via changes in cerebral arterial resistance. CVR is responsible for
maintaining optimal blood flow to meet the energy demand by neurovascular
coupling during neuronal tasks. The defected CVR can cause transient states of
inefficient blood delivery during neural activity leading to subsequent neurodysfunction
and degeneration. CVR is commonly measured with mild hypercapnia (5%CO2) ASL or
BOLD MRI. The purpose of this study was to test the feasibility to measure CVR
using hypercapnia MRI with quantitative susceptibility mapping (QSM) and T2-relaxation-under-spin-tagging
(TRUST) techniques.
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