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Abstract #3350

Cerebrovascular reactivity measured with quantitative susceptibility mapping and TRUST MRI under hypercapnia

Jean-Christophe Brisset1, Olga Marshall1, Louise E Pape1, Hanzhang Lu2, and Yulin Ge1

1Radiology, New York University School of Medicine, New York, NY, United States, 2Radiology, Johns Hopkins University, Baltimore, MD, United States

Cerebrovascular reactivity (CVR) measures the capacity of regulation of blood flow in response to vasoactive stimuli (e.g., CO2) via changes in cerebral arterial resistance. CVR is responsible for maintaining optimal blood flow to meet the energy demand by neurovascular coupling during neuronal tasks. The defected CVR can cause transient states of inefficient blood delivery during neural activity leading to subsequent neurodysfunction and degeneration. CVR is commonly measured with mild hypercapnia (5%CO2) ASL or BOLD MRI. The purpose of this study was to test the feasibility to measure CVR using hypercapnia MRI with quantitative susceptibility mapping (QSM) and T2-relaxation-under-spin-tagging (TRUST) techniques.

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