Abstract #3353

Placebo modulation of brain activity associated with orthodontic pain: a single-blind fMRI Study

Jing Jiang¹, Xin Yang², Wenli Lai², Qiyong Gong¹, and Kaiming Li¹

¹Department of Radiology, Huaxi MR Research Center, West China Hospital of Sichuan University, Chengdu, China, People's Republic of, ²West China Hospital of stomatology, Sichuan University, Chengdu, China, People's Republic of

To investigate the neural mechanism of placebo effects in orthodontic pain, we conducted a fMRI study where twenty-three volunteers, under orthodontic pain induced by separators, were scanned without placebos and followed by another scan with placebos a month later. During both scans, participants were instructed to perform a bite (with maximum strength)/no-bite block design fMRI task. Compared with the non-placebo condition, the participants with placebos demonstrated significant reduced brain activities in multiple regions, including precentral gyrus, superior frontal gyrus, superior parietal lobule and supramarginal gyrus. This study may provide new insights into the neural mechanism of analgesia by placebo.

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