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Abstract #3352

T2 measurements during hyperoxia in the lateral ventricles and peripheral CSF

Jolanda M Spijkerman1, Jill B de Vis1, Esben T Petersen2, Jeroen Hendrikse1, and Jaco J M Zwanenburg1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Centre for Functional and Diagnostic Imaging and Research, Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark

The oxygen tension in CSF and tissue is coupled, but may be easier to measure in CSF. This work investigated the effect of O2 administration on the T2 of CSF. In five subjects, T2s were mapped in the lateral ventricles and the peripheral CSF during administration of a hyperoxic gas mixture (end-tidal O2 level: 500mmHg). In the lateral ventricles no T2 change was observed, in the periphery a significant T2 reduction was found under O2 administration (T2=1.54s) compared to baseline (T2=1.61s), showing the feasibility to use CSF relaxation parameter mapping to detect oxygen tension changes.

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