Abstract #3352

T2 measurements during hyperoxia in the lateral ventricles and peripheral CSF

Jolanda M Spijkerman¹, Jill B de Vis¹, Esben T Petersen², Jeroen Hendrikse¹, and Jaco J M Zwanenburg¹

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Centre for Functional and Diagnostic Imaging and Research, Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark

The oxygen tension in CSF and tissue is coupled, but may be easier to measure in CSF. This work investigated the effect of O₂ administration on the T₂ of CSF. In five subjects, T₂s were mapped in the lateral ventricles and the peripheral CSF during administration of a hyperoxic gas mixture (end-tidal O₂ level: 500mmHg). In the lateral ventricles no T₂ change was observed, in the periphery a significant T₂ reduction was found under O₂ administration (T₂=1.54s) compared to baseline (T₂=1.61s), showing the feasibility to use CSF relaxation parameter mapping to detect oxygen tension changes.

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