Abstract #3355

To Investigate the Regional Functional Connectivity of DMN Alterations in Hypercapnia

Hou-Ting Yang¹, Yi-Jui Liu¹, Tzu-Cheng Chao^2,3, Wen-Chau Chen⁴, Teng-Yi Huang⁵, You-Chia Cheng¹, Hsiao-Wen Chung⁶, Chao-Chun Lin⁷, Chia-Wei Lin⁷, and Wu-Chung Shen⁷

¹Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ²Department of Computer Science and Information Engineering, National Cheng-Kung University, Tainan, Taiwan, ³Institute of Medical Informatics, National Cheng-Kung University, Tainan, Taiwan, ⁴Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, ⁵Department of Eletrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan, ⁶Department of Eletrical Engineering, National Taiwan University, Taipei, Taiwan, ⁷Department of Radiology, China Medical University Hospital, Taichung, Taiwan

To investigate the relationships among regional activity of DMN in different hypercapnia affect using resting-state functional magnetic resonance imaging (rs-fMRI). 10 healthy males were enrolled in this study. A high-resolution T1WI image and BOLD-EPI were performed by a 3 Tesla MR scanner. The CO2 gas mixture (air, 3%, 5% and 7%) was given at the different hypercanpic for each experiment. Our results show that the functional connectivity of DMN is changed in hypercapnia. FC is slight change in 3% CO2 fractions and gradual reduction as the CO2 fraction increases.

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